Tumor Necrosis Factor [TNF] is main cytokine that is involved many pathological condition like inflammation, alzheimer's disease, cancer, major depression and inflammatory bowel disease (IBD), rheumatoid arthritis, asthma, diabetes, diabetes nephropathy, cardiovascular disease, CHF, endothelial dysfunction, neuropathic pain, hepatitis, renal disease, tuberculosis. TNF found in two systemic form known as Tumor Necrosis Factor Alpha [TNF-α] or Tumor Necrosis Factor-Beta [TNF-β]TNF is first produced as a transmembrane protein (tmTNF), which then is cleaved by a metalloproteinase to a soluble form (sTNF). Transmembrane TNF-α is a precursor form of soluble TNF-α that is expressed on TNF-α-producing cells as a homotrimer. The remaining transmembrane TNF-α after cleavage with TACE is further processed by SPPL2b and the intracellular domain is translocated into the nucleus and is supposed to mediate cytokine production. Tm TNF [transmembrane TNF-α] & sTNF [soluble TNF-α]. TNF mediates its pleiotropic activities via two cell surface receptors, p55TNFR (p60, TNFRI, CD120a, utr antigen) and p75TNFR (p80, p70, TNFRII, CD120b, htr antigen).
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